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However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. Ask your health care provider if Allopurinol may interact with other medicines that you take. You will need to discuss the benefits and risks of using Allopurinol while you are pregnant. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency.

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