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However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). If you are or will be breast-feeding while you use Allopurinol , check with your doctor. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. There is no specific information comparing use of allopurinol in the elderly with use in other age groups.
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