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 Brand name: rosiglitazone
Generic name: avandia, Rosiglitazone
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Dose related weight gain has been reported in patients treated with rosiglitazone alone and in combination with other hypoglycemic agents. Dose-related weight gain was seen with rosiglitazone alone and in combination with other hypoglycemic agents. The changes occurred primarily during the first 3 months following initiation of rosiglitazone therapy or following an increase in rosiglitazone dose. Compared to patients receiving placebo, patients with congestive heart failure (CHF) receiving rosiglitazone also experienced more cardiovascular deaths, more CHF worsening, more new or worsening dyspnea, more increases in CHF medication and cardiovascular hospitalization, more myocardial infarctions, and angina. Overall, anemia and edema were generally mild to moderate in severity and usually did not require discontinuation of treatment with rosiglitazone. No increase in fracture rates was observed in men treated with rosiglitazone.

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